With minimal abuse potential and offering the convenience of oral, once-daily administration, pitolisant extends the range of approved treatment options available to adult patients with narcolepsy with or without cataplexy. The prevalence of narcolepsy type 2 (narcolepsy without cataplexy) is uncertain because it is not as well studied and harder to diagnose however, it has been estimated to be 20 to 34 per 100,000 people. This is a medical condition associated with excessive daytime sleepiness, hypnagogic hallucinations, sleep paralysis. Symptoms typically begin to occur between the ages of 10 and 30, although narcolepsy can occur at any age. Narcolepsy without Cataplexy can also be called Narcolepsy Type 2. Narcolepsy with Cataplexy is also known as Narcolepsy Type 1. Consistent with its mechanism of action, the most common treatment-emergent adverse events included headache, insomnia and anxiety. Narcolepsy without cataplexy can be transient, and patients can enter remission 37,38, whereas narcolepsy with cataplexy typically does not remit (remission of this presentation has been reported. Not everyone who has narcolepsy experiences cataplexy. Pitolisant was generally well tolerated in clinical trials. Pitolisant (Wakix ®), an orally available, first-in-class antagonist/inverse agonist of the histamine 3 receptor, is approved in the EU (as of March 2016) for the treatment of narcolepsy with or without cataplexy in adults and in the USA (as of August 2019) for the treatment of excessive daytime sleepiness (EDS) in adults with narcolepsy. Noninferiority of pitolisant to modafinil in the management of EDS was not demonstrated. The totality of evidence from pivotal and supportive phase III trials suggests that pitolisant administered at up to the recommended maximum dose of 36 mg once daily reduces EDS and cataplexy in adults with narcolepsy relative to placebo. Researchers have provided more evidence that narcolepsy without cataplexy (Nw/oC ) and idiopathic hypersomnia (IH) without long sleep time (LST) look more alike on testing than do narcolepsy with cataplexy (NwC) and Nw/oC. Pitolisant was demonstrated to have minimal risk of abuse in preclinical and clinical studies, and is the only anti-narcoleptic drug not scheduled as a controlled substance in the USA. Learn more about their causes, symptoms, and treatments here. Pitolisant (Wakix ®), an orally available, first-in-class antagonist/inverse agonist of the histamine 3 receptor, is approved in the EU (as of March 2016) for the treatment of narcolepsy with or without cataplexy in adults and in the USA (as of August 2019) for the treatment of excessive daytime sleepiness (EDS) in adults with narcolepsy. There are two main types of narcolepsy: type 1, with cataplexy, and type 2, without cataplexy.
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